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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 2
First page : ( 127) Last page : ( 130)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00020.7

A non-cytotoxic pseudo peptide KL1 with potent antioxidant activity

Gangadhara MM1, Dinesha R2, Murari Satish Kumar3,*

1Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore-570 005

2Adichunchanagiri Institute for Molecular Medicine, B.G. Nagara, Mandya-571 448

3Department of Chemistry, PES college of Engineering, Mandya-571401

*Corresponding Author E-mail: murari_sk@hotmail.com, pesmurari@gmail.com

Online published on 17 July, 2017.

Abstract

By incorporating a reduced amide bond Ψ [CH2NH] into α helical antibacterial peptide, we made an attempt to synthesize an antioxidant pseudo peptide. When the pKa value of reduced amide bond is between 6.5 to 7.5, it is protonated depending on the pH. We investigated the antioxidant activity by hydroxyl radical scavenging assay and DPPH radical scavenging assay, the results showed that, the antioxidant activity of KL1 pseudo peptide (51%, 56%) were promising when compared to standard antioxidants like BHA(68%, 78%) and BHT (65%, 81%) respectively. The cyto-toxicity studies of the pseudo peptide showed that the peptide is non-toxic to cells.

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Keywords

Pseudopeptide, Reduced amide bond Selectivity, antioxidant, DPPH radical, Superoxide radical.

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