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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 2
First page : ( 119) Last page : ( 123)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00018.9

Microwave assisted synthesis and antifungal studies of 5-amino thiadiazole substituted pyrimidine compounds

Karthic R1,3,*, Andrews B2,4, Subramani K1,3

1PG & Research Department of Chemistry, Islamiah College, Vaniyambadi-635751, India

3Affiliated to Thiruvalluvar University, Vellore, Tamil Nadu, India

2Department of Chemistry, Priyadarshini Engineering College, Vaniyambadi, India

4Affiliated to Anna University, Chennai, Tamil Nadu, India

*Corresponding Author E-mail: karthicrm@gmail.com

Online published on 17 July, 2017.


Simple synthetic methods of 5-(5-amino-1, 3, 4-thiadiazol-2yl)-3, 4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-thione (3f-j) are described. Compound 1 is converted to carbothiamide 2 by reacting compound 1 with thiosemicarbazide in catalytic amount of acetone is irradiated with help of domestic microwave oven (200W) for 2 minutes. Compound 2 is act as a key intermediate for the final compounds. The compound 2 is converted to corresponding thiadiazole 3 by treatment with conc. H2SO4 and NH3. Structural elucidation is accomplished by IR, 1H and 13CNMR, Elemental analysis and GC-Mass spectral data of the synthesized compounds. Few of these Pyrimidine derivatives have been evaluated for their possible antifungal activity. Most of the tested compounds show significant antifungal activity.



Pyrimidine, thiadiazole, carbothiamide, thiosemicarbazide, antifungal activity.


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