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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 2
First page : ( 119) Last page : ( 123)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00018.9

Microwave assisted synthesis and antifungal studies of 5-amino thiadiazole substituted pyrimidine compounds

Karthic R1,3,*, Andrews B2,4, Subramani K1,3

1PG & Research Department of Chemistry, Islamiah College, Vaniyambadi-635751, India

3Affiliated to Thiruvalluvar University, Vellore, Tamil Nadu, India

2Department of Chemistry, Priyadarshini Engineering College, Vaniyambadi, India

4Affiliated to Anna University, Chennai, Tamil Nadu, India

*Corresponding Author E-mail: karthicrm@gmail.com

Online published on 17 July, 2017.

Abstract

Simple synthetic methods of 5-(5-amino-1, 3, 4-thiadiazol-2yl)-3, 4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-thione (3f-j) are described. Compound 1 is converted to carbothiamide 2 by reacting compound 1 with thiosemicarbazide in catalytic amount of acetone is irradiated with help of domestic microwave oven (200W) for 2 minutes. Compound 2 is act as a key intermediate for the final compounds. The compound 2 is converted to corresponding thiadiazole 3 by treatment with conc. H2SO4 and NH3. Structural elucidation is accomplished by IR, 1H and 13CNMR, Elemental analysis and GC-Mass spectral data of the synthesized compounds. Few of these Pyrimidine derivatives have been evaluated for their possible antifungal activity. Most of the tested compounds show significant antifungal activity.

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Keywords

Pyrimidine, thiadiazole, carbothiamide, thiosemicarbazide, antifungal activity.

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