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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 2
First page : ( 71) Last page : ( 84)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00012.8

Application of Chalcones in Synthesis of Novel 1, 5-Benzodiazepine Derivatives Containing Thieno [2, 3-d] Pyrimidine Core Unit and its Biological Activity Screening

Prabhakar Virupakshi1,*, Babu Kondra Sudhakar2, Ravindranath L.K.2, Basha M. Sahanoor3, Latha J.4

1Faculty of Engineering Chemistry, SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), Andhra Pradesh, India

2Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), India

3Faculty of Engineering Chemistry, SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), Andhra Pradesh, India

4Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S.K. University, Ananthapuramu-515003 (A.P.), India

*Corresponding Author E-mail: viruchem765@gmail.com

Online published on 17 July, 2017.

Abstract

Di azepines, which were synthesized by different methods shown in literature and also Di azepines are great importance in heterocyclic chemistry and more importance in biology and pharmacology. Di azepines are very biological active molecules. In this work A new series of 1, 5-Benzodizepine derivatives were synthesized from chalcones and evaluated for their Antimicrobial activities. First Chalcones were prepared by treatment of Thieno [2, 3-d] pyrimidine-6-carbaldehyde with different acetophenones by Claisen-Schimidt Condensation. Various Benzodiazepines derivatives were prepared by reaction of Chalcone in DMF with o-phenylene di amine in presence of piperidine. The structures of the newly synthesized Benzodiazepine derivatives have been established on the basis of their spectral data. The synthesized selected compounds were evaluated for their antimicrobial activities.

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Keywords

Chalcones, O-phenylene diamine, [1,5]-benzodiazepines, Thieno [2, 3-d] pyrimidines, Antibacterial activity, Antifungal activity.

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