Synthesis, spectral and biological studies of Cd (II) complex of Schiff base ligand derived from 3-hydrazinylquinoxalin-2(1H)-one and 2-hydroxy-3-methoxybenzaldehyde
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The Cd (II) complex of the tridentate Schiff base ligand, 3-(2-(2-hydroxy-3-methoxybenzylidene) hydrazinyl) quinoxalin-2(1H)-one (VHQO) derived from 3-hydrazinylquinoxalin-2(1H)-one and 2-hydroxy-3-methoxybenzaldehyde has been prepared and characterized by IR, UV-VIS, LCMS, CHN analysis, thermo gravimetric analysis, magnetic susceptibility and conductivity measurements. The ligand behaved as uninegative, tridentate, N, N, O donor, coordinating to the metal ion via ring nitrogen, azomethine nitrogen and phenolic oxygen. The ligand formed a monomeric, 1: 1 [Cd(VHQO)Cl] complex. The interactions between the metal complex and calf thymus DNA (CT-DNA) has been studied by absorption spectroscopy. The complex was also screened against two gram positive bacteria Staphyloccocus aureus and Bacillus subtillis, and four gram negative bacteria Escherichia coli, Pseudomonas aeroginosa, Klebsiella pneumonia and Proteus vulgaris. The results indicated moderate activity against Staphyloccocus aureus and Bacillus subtillis.
Schiff base, Tridentate ligand, Antibacterial activity, DNA binding.