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Asian Journal of Pharmacy and Technology
Year : 2019, Volume : 9, Issue : 3
First page : ( 165) Last page : ( 172)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2019.00028.X

Formulation and Evaluation of sustained release Sodium Alginate beads of Indomethacin

Maharjan Sajan*, Prajapati Neha, Shrestha Amit

Department of Pharmacy, Central Institute of Science and Technology (CiST College) (Affiliated to Pokhara University), Sangam Chowk, New Baneshwor, Kahmandu, Nepal

*Corresponding Author E-mail: maharjansajan02@gmail.com

Online published on 31 December, 2019.

Abstract

The present investigation was to design pellets loaded with Indomethacin for extended release. Indomethacin pellets were prepared using sodium alginate as gelling agent (bead forming agent), HPMCK100 as release retardant and Lactose as a diluent in different concentration. Pellets were evaluated for physico-chemical properties such as compatibility, yield value, swelling index, loss on drying, loose surface crystal study, drug content, dissolution and kinetic study. In vitro drug release studies were carried out using USP rotating basket type I method and the samples were analyzed at 318nm by UV spectrophotometer. FT-IR studies revealed that there was no interaction between drug and polymers used in the study. The drug release was found linear in Higuchi plot which confirms that diffusion is one of the mechanisms of drug release. With the help of minitab software optimized formulation was designed whose concentration was sodium alginate 5.31 gm and HPMC K 100 0.64 gm for 100 gm of solution. The optimized formulation has shown the sustained drug release up to 12hrs.

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Keywords

Indomethacin, sodium alginate beads, sustained release.

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