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Asian Journal of Pharmacy and Technology
Year : 2019, Volume : 9, Issue : 2
First page : ( 99) Last page : ( 106)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2019.00017.5

Formulation and Characterization of Atorvastatin Nanocystal Tablet

Gaikwad Nitin A.*, Pujari Abhishek S., Mane Indrajeet V., Vambhurkar Ganesh B., Honmane Pravin P.

Rajarambapu College of Pharmacy, Kasegaon, Dist-Sangli, Maharashtra, India-415404

*Corresponding Author E-mail: nitingaikwadrcp@gmail.com

Online published on 3 July, 2019.

Abstract

The aim of the present study was to investigate the effect of Soluplus on the solubility of atorvastatin and to develop a nanocrystals formulation that can improve the oral bioavailability of atorvastatin. We demonstrated that Soluplus increases the aqueous solubility of atorvastatin. Several nanocrystals formulations of atorvastatin with Soluplus were prepared at using drug: carrier ratio of 1: 1, 1: 1.1, 1: 1.2, 1: 1.3, 1: 1.4, 1: 1.5, 1: 1.6, 1: 1.7, 1: 1.8, 1: 1.9 and 1: 2 by anti-solvent precipitation. Physicochemical analysis demonstrated that atorvastatin is crystalline in each nanocrystals and the 1: 1 drug: carrier ratio provided the highest degree of sustained atorvastatin super saturation. The prepared nanocrystals were characterized by Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimeter, X-ray Diffraction Study, Zeta potential Nuclear magnetic resonance and Scanning Electron Microscopy. Solubility and dissolution study was performed to check the enhanced properties of nanocrystals of atorvastatin. It was observed that, nanocrystals tablet containing nanocrystals exhibited significantly faster solubility and drug dissolution as compared with conventional and marketed tablet of a drug. Amongst all nanocrystals formulations with drug polymer ratio 1: 1 shows highest solubility that is 2.5027±0.77 as compared to pure drug 0.4918±0.51 mg/ml. This increase solubility and dissolution due to increased surface area and characteristics of nanocrystals and soluplus.

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Keywords

Nanocrystals, Soluplus, Atorvastatin, Anti-solvent precipitation, Solubility.

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