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Asian Journal of Pharmacy and Technology
Year : 2019, Volume : 9, Issue : 1
First page : ( 53) Last page : ( 59)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2019.00010.2

Physico-chemical Properties of Solid Drugs: A Review

Kengar Manohar D.*, Howal Rohit S., Aundhakar Dattatray B., Nikam Amit V., Hasabe Priyajit S.

Rajarambapu College of Pharmacy, Kasegaon, Dist-Sangli, Maharashtra, India-415404

*Corresponding Author E-mail: manojkengar200@gmail.com

Online published on 16 March, 2019.

Abstract

The every drug has intrinsic chemical and physical properties in which has been consider before development of pharmaceutical formulation. This property provides great framework for drugs combination with pharmaceutical ingredients in the fabrication of dosage form. The objective of preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic rate profile, compatibility with the other ingredients and establish Physico-chemical parameter of new drug substances. Among these properties, drug solubility, dissolution rate, Particle size partition coefficient polymorphic forms and stability are plays important role in preformulation study. Polymorphism having crystal and amorphous forms shows different chemical physical and therapeutic description of the drug molecule. This article explains some Physical properties and physic-chemical techniques for preformulation evaluation parameters of drug.

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Keywords

Solubility, dissolution, Microscopy, Sieving, Drug excipienent compatibility.

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