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Asian Journal of Pharmacy and Technology
Year : 2019, Volume : 9, Issue : 1
First page : ( 1) Last page : ( 7)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2019.00001.1

Formulation, Optimization and Evaluation of Glibenclamide Transdermal Patches by using chitosan Polymer

Latha AVS Madhu*, Ravikiran T Naga, Kumar J N Suresh

Department of Pharmaceutics, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Andhra Pradesh, India

*Corresponding Author E-mail: satyamadhulatha@gmail.com

Online published on 16 March, 2019.

Abstract

Transdermal drug delivery system (TDDS) also known as “patches “are dosage form designed to deliver the therapeutically effective amount of drug across the patient skin. Glibenclamide is the drug of choice mainly prescribed for the treatment of type 2 diabetes. Oral therapy with Glibenclamide comprises problems of bioavailability fluctuations and may be associated with severe hypoglycaemia and gastric disturbances. As a potential for convenient, safe and effective antidiabetic therapy, the rationale of this study was to develop a TDDS for Glibenclamide. In this study, matrix type transdermal drug delivery system of glibenclamide, an antidiabetic drug were prepared by solvent casting method using different polymers like HPMC, Chitosan in varied ratios. Glycerine was used as plasticizer. Chitosan developing polymer was utilized in TDDS. Chitosan has film forming ability, bioadhesive and absorption enhancing properties. Physical parameters such as moisture content, tensile strength, percentage elongation, and folding endurance were evaluated. Release studies revealed adequate release rates from transdermal films having polymer concentration Chitosan/HPMC (75: 25) D4 showed optimum sustained release characteristics.

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Keywords

Chitosan, HPMC5cps, Glibenclamide, Diabetes, FTIR Studies, plasticizer.

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