(3.239.242.55)
Users online: 2868    [ij] [ij] [ij] 
Email id
 

Asian Journal of Pharmacy and Technology
Year : 2018, Volume : 8, Issue : 3
First page : ( 182) Last page : ( 185)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2018.00029.6

Toxicokinetics-A Review

Merlin N. J.*, Alfiya A. R., Dharan Shaiju S

Department of Pharmacology, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Trivandrum

*Corresponding Author E-mail: merlinbinu76@yahoo.co.in

Online published on 24 October, 2018.

Abstract

Toxicokinetics (TK) is ‘the generation of pharmacokinetic data, either as an integral component in the conduct of non-clinical toxicity studies or in specially designed supportive studies, to assess systemic exposure. Physiologically based toxicokinetic [(PBTK), or alternatively referred to as physiologically based pharmacokinetic (PBPK)] models are quantitative descriptions of absorption, distribution, metabolism, and excretion of chemicals. Toxicokinetics, toxicodynamics and toxicogenomics (TK/TD/TG) methods are the potential tools in human health risk assessment.

Top

Keywords

Toxicokinetics, PBTK model, PBPK model, safety assessment, Drug development.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
470,469,790 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.