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Asian Journal of Pharmacy and Technology
Year : 2018, Volume : 8, Issue : 3
First page : ( 132) Last page : ( 138)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2018.00021.1

Formulation and Evaluation of Mucoadhesive Tablet of Ondansetron HCl

Lalwani Poonam M.*, Dr. Barhate S.D., Bari M.M

Department of Pharmaceutics, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Maharashtra, India, 424206

*Corresponding Author E-mail: lalwanipoonam28@gmail.com

Online published on 24 October, 2018.

Abstract

The aim the study was to prepare and evaluate stomach specific mucoadhesive tablet of ondansetron HCl to remain in the stomach for 12hrs. The mucoadhesive tablets were prepared by wet granulation method using HPMC K100M, carbopol 934p, chitosan and xanthan gum as mucoadhesive polymeric material. Characterization of drug, drug andexcipient compatibility among the formulation component were assessed by FTIR and DSC. It was concluded that A6 batch prepared by using HPMC K100M and chitosan showed good release of drug. It passes as per dissolution acceptance criteria for sustained release formulation. It also showed good mucoadhesive strength.

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Keywords

Ondansetron HCl, mucoadhesive tablets, HPMC K100M, chitosan, carbopol, xanthangum.

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