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Asian Journal of Pharmacy and Technology
Year : 2018, Volume : 8, Issue : 2
First page : ( 103) Last page : ( 107)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2018.00016.8

Application of UV Spectrophotometric Methods for Simultaneous Estimation of Emtricitabine and Tenofovir Alafenamide Fumarate in Bulk

Shelke Ashwini*, Shinde Madhavi1, Mogal Rajendra2, Sable Rahul3, Dr. Jadhav Anil4

1Department of Pharmaceutical Chemistry, Sandip Institute of Pharmaceutical Sciences, Nashik, India-422213

2Department of Pharmaceutics, Sandip Institute of Pharmaceutical Sciences, Nashik, India-422213

3Department of Pharmacology, Sandip Institute of Pharmaceutical Sciences, Nashik, India-422213

4Department of Pharmacognosy, Sandip Institute of Pharmaceutical Sciences, Nashik, India-422213

*Corresponding Author E-mail: shelke.ashwini2@gmail.com

Online published on 21 July, 2018.

Abstract

Two simple method was developed for the simultaneous determination of tenofovir alafenamide fumarate (TAF) and emtricitabine (EMT) in combined tablets. The method involves the Simultameous equation method (Method A) and Q-Absorabnce Method (Method B). Tenofovir (TEF) has λmax 260nm and Emtricitabine (EMT) shows λmax at 237nm and 280nm both. Tenofovir and 280nm shows linearity in a concentration range of 5–30 μg/mL and employs formation and solving of simultaneous equation using wavelengths for both drugs using Distilled water. Method B employs measurement using 237nm (λmax of EMI) and 251nm as Iso-absorptive Point.

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Keywords

Tenofovir Alafenamide fumarate, Emtricitabine, Multicomponent analysis, ICH guideline, Validation.

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