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Asian Journal of Pharmacy and Technology
Year : 2018, Volume : 8, Issue : 2
First page : ( 92) Last page : ( 102)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2018.00015.6

Formulation Development and Evaluation of Nasal In-Situ Gel of Hydrocortisone

Khandagale Pradnya M1,*, Rokade Manisha M.2, Phadtare Dipti G.3

1Department of Quality Assurance Techniques, R. G. Sapkal Institute of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

2Department of Quality Assurance Techniques, R. G. Sapkal Institute of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

3Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

*Corresponding Author E-mail: pradnyamkhandagale@yahoo.in

Online published on 21 July, 2018.

Abstract

Over a few decades, advances in the in-situ gel technologies have spurred development in may medical and biomedical applications including controlled drug delivery. For locally acting intra nasal drugs, an extended residence time in the nasal cavity is desirable and related to a prolonged effect. The aim of the present work was to design a nasal delivery system with improved mucoadhesive properties that could provide prolonged retention time for the treatment of the allergic rhinitis. A 32 factorial design was used to investigate the effect of amount of Poloxamer 188 and carbopol 934as an independent variables. % drug release and mucoadhesive strength were taken as dependant variables. The formulations were tested for gelation study, viscosity study, gel strength, mucoadhesion study, drug content and stability study. Gelation was determined by physical appearance, viscosity study of solution and gel formulations indicated that increase in polymer concentration increase the viscosity. Gel strength was found in the range of 0.55–2.36 sec. The mucoadhesive force in terms of detachment stress increase with increase in the concentration of carbopol 934. A stability study for optimized formulation as per ICH guideline for 90 days showed no change in pH, drug content and viscosity. The developed in-situ gelling system for Hydrocortisone using poloxamer188 in combination with carbopol 934 with improved mucoadhesive properties that could provide prolonged retention time for the tratement of allergic rhinitis.

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Keywords

32 factorial design, in-situ nasal gel, Hydrocortisone, mucoadhesive.

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