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Asian Journal of Pharmacy and Technology
Year : 2018, Volume : 8, Issue : 2
First page : ( 78) Last page : ( 82)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2018.00012.0

Preparation of Sustained Release Matrix Dispersion type Transdermal films of Lornoxicam

Dr. Baggi Ravindra Babu*

Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Hyderabad-502 313

*Corresponding Author E-mail: baggi.ravi69@gmail.com

Online published on 21 July, 2018.

Abstract

Transdermal drug delivery systems of Lornoxicam have been formulated by using solvent casting method. Matrix patches were prepared by using Chitosan and different grades of hydroxyl propyl methyl cellulose (HPMC) as polymers by incorporating glycerol as plasticizer and Tween-80 as permeation enhancer. All the patches were uniform with respect to physicochemical and FTIR evaluation. The in vitro permeation studies indicated that matrix patches containing Chitosan: HPMCk100 in the ratio of 1:2 shown better release. Tween-80 was incorporated to enhance the permeation of drug. The formulation containing 30% w/w glycerol has exhibited better enhancement for the permeation of Lornoxicam. Skin irritation study revealed that the free of irritation.

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Keywords

Lornoxicam, NSAID, TDDS, Permeation, Analgesic and Anti-inflammatory, Chitosan, HPMC.

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