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Asian Journal of Pharmacy and Technology
Year : 2018, Volume : 8, Issue : 2
First page : ( 65) Last page : ( 70)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2018.00010.7

Formulation and Evaluation of Valsartan Pulsincap Drug Delivery System for Treatment of Hypertension

Patil Omkar A.1,*, Patil Indrajeet S.1, Bilsakar Vishal V.1, Randive Dheeraj S.1, Bhutkar Mangesh A.1, Bhinge Somnath D.2

1Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India

2Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India

*Corresponding Author E-mail: omkarpatil3332@gmail.com

Online published on 21 July, 2018.

Abstract

The aim of the present study was to develop and evaluate pulsatile drug delivery system of Valsartan for the treatment of hypertension. It is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack. It is an angiotensin II receptor antagonist that is selective for the type I angiotensin receptor. Capsule body was made water insoluble by cross linking with formaldehyde vapor. Formalin treatment has been employed to modify the solubility of gelatin capsules. Quantitative test for formalin residue was carried out. FTIR study shown drug and excipient are compatible with each other. Hydrogel plug of various components were prepared and used in pulsincap formulation. The drug content of the formulated pulsincap was found to be in the range 85.88 to 90.36%. In vitro drug release study in pH 1.2 buffer was observed to be zero percent and capsule was intact for first 2 hrs during the study. F2 formulation batch was selected as best formulation as it exhibited maximum drug release of 90.36% in pH 7.4 phosphate buffer as compared with other formulation batches. Pulsincap formulations of can be suitable for optimum colonic delivery of valsartan in the treatment of hypertension as per chronotherapy.

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Keywords

Pulsatile, Pulsincap, Circardian Rhythm, Valsartan, Hypertension.

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