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Asian Journal of Pharmacy and Technology
Year : 2018, Volume : 8, Issue : 1
First page : ( 52) Last page : ( 62)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2018.00009.0

Gold Nanoparticle-Small Drug Molecule Conjugates: Therapeutic Applications and Benefits as Compared to Free Drug

Kumar Pravin*, Ashawat Mahendra Singh, Pandit Vinay

Department of Pharmaceutics, Laureate Institute of Pharmacy, Kangra, H. P, India-177101

*Corresponding Author E-mail: kumar3785@gmail.com

Online published on 2 June, 2018.

Abstract

Gold nanoparticles (AuNPs) have been profoundly investigated for drug delivery applications. Various widely used small drugs molecules when conjugated either covalently or non-covalently with the AuNPs, showed improved therapeutic effect with reduced dose and adverse effects as compared to drug alone. This review focuses on therapeutic efficiency of AuNPs-small drug molecule conjugates as anti-cancer, anti-bacterial, antiretroviral and anti-arthritic agents. The basic approaches of conjugation, brief of procedure followed for activity determination and mechanism of action of conjugates have also been discussed.

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Keywords

Gold, Nanoparticles, Drug conjugates, Anti-cancer, Anti-bacterial, Drug delivery.

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