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Asian Journal of Pharmacy and Technology
Year : 2017, Volume : 7, Issue : 4
First page : ( 181) Last page : ( 188)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2017.00029.0

Formulation Development of Propranolol Hydrochloride Sustained Release Prunus amygdalus Gum Based Mucoadhesive Buccal Matrices

Shende M. A.*, Gupta P. K.

Department of Pharmaceutics, Government College of Pharmacy, Kathora Naka, Amravati-444604, India

*Corresponding Author E-mail: shende_mulchand@rediff.com

Online published on 2 June, 2018.

Abstract

Sustaining the release of drug from dosage form is useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The objective of the present work was to develop sustained release propranolol hydrochloride mucoadhesive buccal matrix tablets using natural and synthetic polymers. Matrix tablets were prepared by direct compression method using backing layer on three sides of matrices and evaluated for various physical parameters. Quality control parameters followed by optimization was employed to get final optimized formulation. Among all the formulations, F8 shows 72.85% better sustained release at the end of 4.5 hrs. The release co-efficient values ‘n’ (>0.5) indicated that the drug release followed non-fickian anomalous mechanism based on formulation factors. The stability studies were carried out according to ICH guideline which indicates that the selected formulation was stable. Propranolol HCl matrices could be developed mucoadhesive nature with desirable release modulation for buccal administration.

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Keywords

Propranolol HCl (PPPNL HCl), Prunus amygdalus gum, Carbopol, Matrices.

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