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Formulation Development of Propranolol Hydrochloride Sustained Release Prunus amygdalus Gum Based Mucoadhesive Buccal Matrices Shende M. A.*, Gupta P. K. Department of Pharmaceutics, Government College of Pharmacy, Kathora Naka, Amravati-444604, India *Corresponding Author E-mail: shende_mulchand@rediff.com
Online published on 2 June, 2018. Abstract Sustaining the release of drug from dosage form is useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The objective of the present work was to develop sustained release propranolol hydrochloride mucoadhesive buccal matrix tablets using natural and synthetic polymers. Matrix tablets were prepared by direct compression method using backing layer on three sides of matrices and evaluated for various physical parameters. Quality control parameters followed by optimization was employed to get final optimized formulation. Among all the formulations, F8 shows 72.85% better sustained release at the end of 4.5 hrs. The release co-efficient values ‘n’ (>0.5) indicated that the drug release followed non-fickian anomalous mechanism based on formulation factors. The stability studies were carried out according to ICH guideline which indicates that the selected formulation was stable. Propranolol HCl matrices could be developed mucoadhesive nature with desirable release modulation for buccal administration. Top Keywords Propranolol HCl (PPPNL HCl), Prunus amygdalus gum, Carbopol, Matrices. Top | |
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