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Asian Journal of Pharmacy and Technology
Year : 2017, Volume : 7, Issue : 3
First page : ( 157) Last page : ( 165)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2017.00026.5

Antidiabetic efficacy of Methanol extract Brown Alga Lobophora variegata on Alloxan stimulated Hyperglycemic Wistar Albino Rats

Thennarasan Sathyaseelan1, Murugesan Subbiah1, Sivamurugan Vajiravelu2,*

1Division of Algal Biotechnology and Bionano Technology, Post Graduate and Research Department of Botany, Pachaiyappa's College, Chennai-600 030, India.

2Post Graduate and Research Department of Chemistry, Pachaiyappa's College, Chennai-600 030, India.

*Corresponding Author E-mail: sivaatnus@gmail.com

Online published on 17 October, 2017.

Abstract

To investigate the effect of methanol extract of Lobophora variegata for its antihyperglycemic activity against alloxan induced diabetic rats. The methanol residue of Lobophora variegata was given orally at a dosage of 10 mg/kg weight to diabetic animals for about 28 days. The outcome of algae residue feeding was estimated by various biochemical and haematological parameters such as RBC, WBC, HB and platelets and lipid profile. Histopathological evaluation was made in the pancreas. After feeding of methanol extract in diabetic rats for 28 days, the blood glucose has significantly decreased, while the increase in liver glycogen level was observed. In addition, the regeneration of the pancreas of the treated animals was also noticed. The methanol residues of the Lobophora variegata possess very effective anti-hyperglycemic activity on the diabetic rats as compared to Glipizide.

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Keywords

Lobophora variegata, Alloxan monohydrate, Carbohydrate metabolism, Diabetes mellitus, Brown algae.

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