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Asian Journal of Pharmacy and Technology
Year : 2017, Volume : 7, Issue : 2
First page : ( 109) Last page : ( 114)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2017.00019.8

Synthesis, Characterization, Docking study and Anti-Bacterial Evaluation of Benzimidazole Derivatives as Biotin Carboxylase Inhibitors

Hemalatha K., Raj D. Niranjan, Begam M. Fousia, Sharanya V.K., Girija K.

Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Government of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-06., India

Online published on 18 September, 2017.

Abstract

A series of some novel mannich bases substituted Benzimidazole derivatives were synthesized by condensing Benzimidazole with various aromatic aldehydes and different amino compounds in the presence of ethanol. The purity of the compounds were checked by thin Layer Chromatography and Melting point determination method. The functional group of the compounds were characterized by FT-IR spectroscopy. The Structures of the synthesized compounds were optimized with Auto Dock 4.0.1 to investigate the interaction between the target ligand and the amino acid residues of Biotin Carboxylase to determine the probable model. The title compounds were subjected to preliminary QSAR study using Molinspiration software. All the newly synthesized benzimidazole derivatives were evaluated for their invitro anti-bacterial activity by disc diffusion method by measuring the zone of inhibition and the results were comparable to standard.

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Keywords

Benzimidazole, Mannich Base, Auto Dock, Biotin carboxylase, Anti-bacterial activity.

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