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Asian Journal of Pharmacy and Technology
Year : 2017, Volume : 7, Issue : 2
First page : ( 86) Last page : ( 90)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2017.00015.0

Activity of Antimalarial Compounds from Ethyl Acetate Fraction of Sunflower Leaves (Helianthus annuus L.) against Plasmodium falciparum Parasites 3D7 Strain

Mutiah Roihatul1,*, Badiah Riadul2, Hayati Elok Kamilah2, Widyawaruyanti Aty3

1Department of Pharmacy, Faculty of Medicine and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim Malang

2Chemistry Department Faculty of Science and Technology, Universitas Islam Negeri Maulana Malik Ibrahim Malang Maulana Malik Ibrahim Malang

3Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga

*Corresponding Author E-mail: roiha@farmasi.uin-malang.ac.id

Online published on 18 September, 2017.

Abstract

Antimalarial study using methanol extract and ethyl acetate fraction of sunflower leaves had been done. The study was conducted to know antimalarial activity between methanol extract and ethyl acetate fraction at Plasmodium falciparum parasites 3D7 strain. Separation of compounds was done by maceration using methanol and partition using ethyl acetate. Identification of ethyl acetate fraction was done by using UPLC-MS instrument. The results shown ethyl acetate fraction obtained the highest peak based on database were artemisinin, heliangolide, linolenic acid, linoleic acid eupalinolide C. The results of antimalarial study shown that methanol extract had IC50 22.18 mg/mL, and ethyl acetate fraction had IC50 16.68 mg/mL. Antimalarial activity between methanol extract and ethyl acetate fraction showed no significant difference.

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Keywords

Sunflower leaves, Antimalarial, Plasmodium falciparum Strain 3D7, UPLC-MS.

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