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Asian Journal of Pharmacy and Technology
Year : 2017, Volume : 7, Issue : 1
First page : ( 37) Last page : ( 50)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2017.00007.1

Insilico Analysis of Sesamum indicum Seed Proteins

Narasimhan Rangarajan*, Mohan Ambilly

Dept. of Biochemistry, Sri Sankara Arts and Science College, Enathur, Kanchipuram-631561, Tamil Nadu, India

*Corresponding Author E-mail: n.rangarajan@yahoo.co.in

Online published on 18 September, 2017.

Abstract

Many infectious diseases have been known to be treated with herbal remedies throughout the history of mankind. The use of herbal medicines in science in an evidence based manner is called phytotherapy. Natural products, either as pure compounds or standardized plant extracts provide unlimited opportunities for new drug release because of chemical diversity. In the present study, an attempt has been made to quantitate proteins in sesame seeds, to separate proteins by SDS PAGE and to analyse the molecular weight by marker protein. The current study also aimed to conduct multiple sequence alignment, similarity searches and secondary structure prediction of the major globulins in sesame seeds (7S globulin and 11S globulin) using bioinformatics tools. The study of protein shows that the sequences of 7Sglobulin and 11S globulin of Sesamum indicum have greater sequence homology with 7S globulin of Elaeis guineensis var tenera and 11S storage globulin of Coffea arabica respectively. The results also reveal the presence of alpha helix, extended strand and random coils in7S and 11S globulin with a high occurrence of random coils in both the globulin subunits.

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Keywords

Sesamum indicum, globulin, BLAST, Multiple sequence alignment, FASTA.

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