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Asian Journal of Pharmacy and Technology
Year : 2017, Volume : 7, Issue : 1
First page : ( 19) Last page : ( 26)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2017.00004.6

Optimization of Various Grades of HPMC for Development of Sustained Release Matrix Tablets of Theophylline.

Madhukar Godbole Ajeet1, Patel Bhautik V2, Narayan Somnache Sandesh1,*, Prajapati Ashish R2, Pradeep Yadav2

1Department of Pharmaceutics, PES'S Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda-403401, Goa, India

2Department of Pharmaceutics, S.E.T'S College of Pharmacy, Dharwad, Karnataka (India)

*Corresponding Author E-mail: sandeshsomnache@gmail.com

Online published on 18 September, 2017.

Abstract

Theophylline is a bronchodilator drug, used in treatment of asthma. The conventional dosage forms of Theophylline releases the entire drug in just few minutes and therefore the therapeutic concentrations will be maintained for a short period of time. This may leads to administration of subsequent dose. To overcome this, present study was aimed to develop the dosage form of Theophylline which will release the drug up to 12 hours. The matrix tablets of Theophylline were developed using different concentrations of various grades of HPMC and were evaluated for various pre-compression and post compression parameters. The data obtained was analyzed using linear model (Historical Data) of Design Expert 8.0.7.1(Trial version). Based on the results obtained, it was concluded that the Formulation F9 containing HPMC E15LV is suitable to develop sustained release matrix table of Theophylline which can release more than 50% drug in first 5 hours and more that 90% of the drug at the end of 9th hour extended up to 12 hours.

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Keywords

Swellable polymer, optimization of formulation, design of experiment, theophylline matrix tablet.

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