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Asian Journal of Pharmacy and Technology
Year : 2016, Volume : 6, Issue : 3
First page : ( 183) Last page : ( 185)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2016.00026.X

Preparation and Evaluation of Fast Dissolving Tablet Tramadol Hydrochloride

Patil Rohan, Patil Neha, Patil Aniket, Shid S. J.*, Dange V.N., Magdum C.S., Mohite S.K.

Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara

*Corresponding Author E-mail: Shubhangishid@gmail.com

Online published on 18 October, 2016.

Abstract

Novel drug delivery system assists to achieve better patient compliance. Fast dissolving tablets are one of them. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. FDDT formulation combines the advantage of both liquid and conventional tablet formulation while also offering advantage over both traditional dosage forms. This review gives a view of advantages, limitations, need for formulating FDTS, Formulation factors, excipients used, and methodology and evaluation parameters.

Fast dissolving tablets (FDTs) can be prepared by different methods, such as direct compression, freeze-drying, spray drying, sublimation, wet granulation method4. The basic approach for the development of FDTs is the use of superdisintegrants. The aim of this study was to formulate FDTs with sufficient mechanical integrity and to achieve faster disintegration in the oral cavity without water. To achieve this goal, mannitol used as diluent as well as sweetening agent for the formulation of tablets. Attempts were made to enhance dissolution rate along with faster disintegration using superdisintegrants, like microcrystalline cellulose. Tramadol hydrochloride, a centrally acting synthetic opioid analgesic, was selected as the active pharmaceutical ingredient in the study.

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Keywords

Tramadol hydrochloride, Direct Compression method, Microcrystalline cellulose.

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