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Asian Journal of Pharmacy and Technology
Year : 2016, Volume : 6, Issue : 2
First page : ( 131) Last page : ( 134)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2016.00018.0

A Review on Self-Micro Emulsifying Drug Delivery System: Evident to improve the oral bioavailability of hydrophobic drugs

Khairnar Dhiraj A.1,*, Darekar Avinash B.1, Saudagar Ravindra B.2

1Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjaneri, Dist. Nashik-422212, Maharashtra, India

2Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjaneri, Dist. Nashik, 422212, Maharashtra, India

*Corresponding Author E-mail: dhirajkhairnar90@gmail.com

Online published on 21 June, 2016.

Abstract

The SMEDDS are the isotropic mixture of oil, surfactant and co-surfactant. SMEDDS solve the problem of all BCS class of drug such as solubility, high molecular weight, pre systemic first pass effect, enzymatic degradation, gastric irritation and also increase the bioavailability and stability of drug. Currently a number of technologies are available to deal with the poor solubility, dissolution rate and bioavailability of insoluble drugs one of them is Self-Micro Emulsifying Drug Delivery Systems (SMEDDS). lipid based formulations, self-microemulsifying formulations (droplet size <100 nm) are evident to improve the oral bioavailability of hydrophobic drugs primarily due to their efficiency in facilitating solubilization and in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented.

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Keywords

SMEDDS, Hydrophobic drugs, surfactant, oil, co-surfactant, bioavailability.

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