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Asian Journal of Pharmacy and Technology
Year : 2016, Volume : 6, Issue : 2
First page : ( 99) Last page : ( 105)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2016.00014.3

Effect of Various Super Disintegrants on the Drug Release Profile of Orally Disintegrating Tablets

Swamy S. Kumara1,*, Arun G.1, Srinivas Bethi1, Goud Agaiah B2

1Department of Pharmaceutics, Talla Padmavathi College of Pharmacy Orus, Kareemabad, Warangal, Telangana, India

2Department of Pharmaceutics, S.R.R. College of Pharmaceutical Sciences, Valbhapur, Elkathurthy, Karimnagar-505 476, Telangana, India

*Corresponding Author E-mail: kumar4koty@gmail.com

Online published on 21 June, 2016.

Abstract

Pharmaceutical technologists have developed a novel oral dosage form which disintegrate rapidly in saliva, usually in a matter of seconds, without the need to take it water. The novel orally disintegrating tablet dosage form is used to improve patient convenience and compliance for administration of various therapeutic agents. Propranolol is metabolized in the liver during its first passage through the systemic circulation and has about 25% of the oral bioavailability. The aim of the present study was to develop and optimize orally disintegrating tablets of propranolol hydrochloride by using super disintegrants to give quick onset of action by rapidly disintegrating in a few seconds. Tablets were prepared by direct compression method using flat face 8mm size punch and evaluated hardness, thickness, weight variation, friability, drug content and dissolution tests and all the tests results are found to be within the pharmacopoeial limits. The drug release was rapid in formulation containing crospovidone as super disintegrants, followed by croscaramellose sodium and sodium starch glycolate. Crospovidone super disintegrants concentration in 15mg or 6% is suitable for the formulation of oral disintegrate tablets of Propranolol Hydrochloride.

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Keywords

Orally disintegrating tablets, Super disintegrants, crospovidone, Propranolol HCl.

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