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Asian Journal of Pharmacy and Technology
Year : 2015, Volume : 5, Issue : 1
First page : ( 38) Last page : ( 49)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2015.00008.2

A Review-Emerging Use of Nano-Based Carriers in Diagnosis and Treatment of Cancer-Novel Approaches

Mohd. Khan Yaqub1,*, Saroj Brijesh Kumar2, Roy Maryada3, Dr. Aziz Irfan4

1Azad Institute of Pharmacy & Research Azadpur, Adjacent CRPF Camp, Bijnour, Lucknow -226 002, Uttar Pradesh, India

2Goel Institute of Pharmacy & Sciences, Lucknow, Uttar Pradesh, India

3Mangalayatan University, Beswan, Aligarh, Uttar Pradesh, India

4Azad Institute of Pharmacy & Research Azadpur, Adjacent CRPF Camp, Bijnour, Lucknow -226 002, Uttar Pradesh, India

*Corresponding Author E-mail: khanishaan16@yahoo.com

Online published on 2 May, 2015.

Abstract

Despite intensive research efforts, cancer remains one of the leading causes of death in the world. Many new methods and techniques have been developed in order to improve diagnosis and treatment, often promising in the beginning, but with limited results during the course of their application. In recent years, there has been an unprecedented expansion in the field of nanomedicine with the development of new nanoparticles for the diagnosis and treatment of cancer. Nanoparticles have unique biological properties given their small size and large surface area-to-volume ratio, which allows them to bind, absorb, and carry compounds such as small molecule drugs, DNA, RNA, proteins, and probes with high efficiency. Their tunable size, shape, and surface characteristics also enable them to have high stability, high carrier capacity, the ability to incorporate both hydrophilic and hydrophobic substances and compatibility with different administration routes, thereby making them highly attractive in many aspects of oncology. The expansion of novel nanoparticles for drug delivery is an exciting and challenging research filed, in particular for the delivery of emerging cancer therapies, including small interference RNA (siRNA) and microRNA (miRNAs)-based molecules.

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Keywords

Nonomedicine, Nanoparticles, Oncology.

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