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Asian Journal of Pharmacy and Technology
Year : 2015, Volume : 5, Issue : 1
First page : ( 13) Last page : ( 16)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2015.00003.3

Absorption Correction Method for Simultaneous Estimation of Nifedipine and Metoprolol Succinate in Their Synthetic Mixture Using From Spectrophotometry

Rajanit Sojitra*, Paras Virani, Raj Hashumati

Department of Quality Assurance, Shree Dhanvantry Pharmacy College, Kim, Surat

*Corresponding Author E-mail: rajanit.sojitra@gmail.com

Online published on 2 May, 2015.

Abstract

A new simple, economical, precise and accurate method are described for the simultaneous determination of Nifedipine (NIF) and Metoprolol Succinate (MET) in combined tablet dosage form. The proposed method was applied for the determination of Nifedipine and Metoprolol Succinate in synthetic mixture, for determination of sampling wavelength, 10μg/ml of each of NIF and MET were scanned in 200–400 nm range and sampling wavelengths were 313nm for NIF and 275.40nm for MET are selected for development and validation of absorption correction method. For this method linearity observed in the range of 5–25μg/ml for NIF and 25–125μg/ml for MET, and in their pharmaceutical formulation with mean percentage recoveries 100.68 and 100.33, respectively. The method was validated according to ICH guidelines and can be applied for routine quality control testing.

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Keywords

Spectroscopic method, absorption correctedmethod, Nifedipine and Metoprolol Succinate.

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