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Asian Journal of Pharmacy and Technology
Year : 2020, Volume : 10, Issue : 2
First page : ( 81) Last page : ( 84)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2020.00015.X

Preparation and In vitro Characterisation Venlafaxine HCl Controlled Release Tablets

Dr. Reddy Y. Krishna*, Giri K.

Department of Pharmaceutics, Nalanda College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana

*Corresponding Author E-mail: rajinisuralabs1@gmail.com

Online published on 3 June, 2020.

Abstract

The aim of the present study was to develop Controlled release formulation of Venlafaxine HCL to maintain constant therapeutic levels of the drug for over 12 hrs. Eudragit S 100, HPMC K4 M and HPMC K15 M were employed as polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Whereas from the dissolution studies it was evident that the formulation (F5) showed better and desired drug release pattern i.e., 98.46% in 12 hours. It contains the synthetic polymer HPMC K4 M as controlled release material. It followed zero order release kinetics mechanism.

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Keywords

Venlafaxine HCL, Eudragit S 100, HPMC K4 M, K15 M, Controlled release tablets.

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