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Asian Journal of Pharmacy and Technology
Year : 2020, Volume : 10, Issue : 2
First page : ( 71) Last page : ( 80)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2020.00014.8

Formulation development and Evaluation of Cleome gyandra based gel

Thombre Nilima A.1,*, Gaikwad Swati Madhukar1,**, Kshirsagar Sanjay J.1, Attarde Daksha2

1Department of Pharmaceutics, MET Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nasik-422003, Maharashtra, India

2Department of Pharmacognosy, MGV'S College of Pharmacy, Nashik

*Corresponding Author E-mail: nilimathombre@gmail.com

**swatigaikwad092@gmail.com

Online published on 3 June, 2020.

Abstract

The plant Cleome gyandra family Cleomaceae has analgesic activity. Extraction of whole plant was done using by drying and grinding whole plant in water and ethanol solvent by using soxhlet apparatus. flavonoids and tannins present in the plant are responsible for the analgesic activity. Herbal gel was developed using laboratory collected water and ethanol extract whereas water extract contains tannin and ethanol extract contains flavonoids. Herbal gel formulation was prepared by using different concentration of gelling agent like carbapol940, different concentration of tannin and flavonoids obtained from water and ethanol extract. Herbal gel was evaluated using parameter such as physical appearance like color, Odor, Consistency, pH, Viscosity, Spreadability, Drug content etc. Topical gel formulations had pH in the range of 6.8–7.2 i.e. in the neutral range. Viscosity of gel was determined by Brookfield viscometer, viscosity were determined, Batches F2, F6 and F8 had high viscosity as compared to other batches of gel. The spreadability of the gel formulations was determined, by measuring 1gm of gel between horizontal plates after 1 min. the standardized weight tied on the upper plate. Spreadability values of the formulation (F1-F9) were determined. Batches F1-F4 has higher spreadability value in comparison with others batches of gel. The analgesic activity of plant extract was detected by in vivo study like skin irritation method and acetic acid induced writing test. The prepared herbal gel was evaluated for its skin irritant effect, where no erythema or edema was observed for all the formulations F1 to F9 after 24 hours.

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Keywords

Cleome gyandra, analgesic activity, Gel Evaluation, Skin irritation, acetic acid induced writhing test.

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