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Asian Journal of Pharmacy and Technology
Year : 2020, Volume : 10, Issue : 1
First page : ( 1) Last page : ( 6)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2020.00001.X

Comparative Assessment of Multi brand and Generic Methylprednisolone tablets marketed in India

Sinha Yash1, Patel Kuldeep Singh1,2,*, Rathi Vaishali1, Rathi Jagdish Chandra1, Singh Archana3

1NRI Institute of Pharmaceutical Sciences, Sajjan Singh Nagar, Bhopal, M.P, (India), 462021

2Department of Pharmacy, NRI Institute of Research and Technology, Sajjan Singh Nagar, Bhopal, M.P (India) 462021

3Govt. Degree College, Timrani, M.P, India

*Corresponding Author E-mail: kuldeeppatelrgpv@gmail.com

Online published on 3 June, 2020.

Abstract

The research on the topic of branded and generic drug comparison always provides an interesting perspective among pharmacy stakeholders. Physicians often continue to prescribe brand name drugs from the country of origin of the inventor to their patients even when less expensive of same brand drugs that are available in India. A one-sided assertion from drug manufacturers about the equivalent quality of generic drugs with the branded products raises the pros and cons in the community, including the health-care providers. Methylprednisolone (MP) is a corticosteroid hormonal. This drug is commonly used to treat many different conditions such as skin problems, allergic reactions, arthritis, lupus, and other disorders. The comparative pharmacodynamics effect between branded and generic products of MP tablets in the present study was investigated in vivo. The physical parameters i.e. Price variation, weight variation, thickness, hardness, disintegration, dissolutions and chemical assay were considered during the present study. All products had contents compatible within the Pharmacopeias and the dissolution were determined in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) without enzymes for all the drugs showed more than 92% of the API dissolved within 30 minutes. All drugs were approved with regard to tablets pharmacopical parameters are between within the limit. The disintegration time of all samples also proved satisfactory, had completely disintegrated in less than 15 seconds. The SGF indicated over 90% release from eight samples, while it revealed over 81% release in SIF from nine samples out of the above mentioned.

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Keywords

Branded drug, Generic, Methylprednisolone, Simulated gastric fluid, Multibranded.

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