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Asian Journal of Pharmaceutical Research
Year : 2019, Volume : 9, Issue : 4
First page : ( 299) Last page : ( 306)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2019.00047.9

Schiff bases and Bicyclic derivatives comprising 1, 3, 4-thiadiazole moiety-A Review on their Pharmacological activities

Hameed Sherin A.1,*, Varkey Joyamma2, Jayasekhar P.3

1College of Pharmaceutical Sciences, Govt. Medical College, Thiruvananthapuram-695011

2College of Pharmaceutical Sciences, T.D Medical College, Alappuzha-688005

3College of Pharmacy, National University of Science and Technology, Muscat, Oman

*Corresponding Author E-mail: sherinirshad@gmail.com

Online published on 31 December, 2019.

Abstract

1, 3, 4-thiadiazole is a well-known heterocyclic nucleus which form an integral feature of various natural products and medicinal agents. It has enormous biological potential due to their privileged structure and is able to undergo various chemical reactions which make researcher more comfortable in drug designing. The stability of thiadiazole nucleus has inspired medicinal chemist to carryout various structural variations in the ring. This review highlights the pharmacological activity of recently synthesized Schiff bases and fused ring systems comprising1, 3, 4-thiadiazole moiety.

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Keywords

1, 3, 4-thiadiazole, Schiff bases, triazolothiadiazole, antimicrobial activity, anticonvulsant activity, antioxidant activity, anticancer activity, antidiabetic activity, antidepressant activity.

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