(18.207.102.38)
Users online: 1720    [ij] [ij] [ij] 
Email id
 

Asian Journal of Pharmaceutical Research
Year : 2019, Volume : 9, Issue : 2
First page : ( 97) Last page : ( 103)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2019.00016.9

Sublingual Tablets-An Updated Review

Thulluru Ashok*, Mahammed Nawaz, Madhavi C., Nandini K., Sirisha S., Spandana D.

Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati-517 102, Chittoor (Dist.), Andhra Pradesh, India

*Corresponding Author E-mail: ashokthulluru@gmail.com

Online published on 3 July, 2019.

Abstract

Introduction

Sublingual drug delivery can be an alternative and better route when compared to oral drug delivery as sublingually administered dosage forms bypass hepatic metabolism. A rapid onset of pharmacological effect is often desired for some drugs, especially those used in the treatment of acute disorders. Sublingual tablets disintegrate rapidly and the small amount of saliva present is usually sufficient for achieving disintegration of the dosage form coupled with better dissolution and increased bioavailability.

Approach

Published articles from PubMed and other standard sources were utilized to review and compile an overview of sublingual tablets and the benefits of the sublingual route of administration.

Findings

Sublingual tablets were found to have better characteristics when compared to conventional dosage forms. Sublingually administered tablets achieved better bioavailability, rapid onset of action and better dissolution properties due to fast disintegration. The addition of super-disintegrants facilitated rapid disintegration and this approach can be used to treat acute disorders or emergency conditions.

Conclusion

Sublingual tablets or any sublingual dosage form can be used to achieve a rapid onset of action, better patient compliance and increased bioavailability. The sublingual route of administration can be used for drugs which undergo extensive first pass metabolism or degradation in the GIT. Drugs administered sublingually tend to have better bioavailability which correlates to dose reduction when compared to conventional oral tablets.

Top

Keywords

Sublingual tablets, self-medication, fast disintegration, increased bioavailability.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
452,876,685 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.