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Year : 2019, Volume : 9, Issue : 2
First page : ( 63) Last page : ( 68)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2019.00010.8

Absorbance Ratio Method of Vortioxetine and Aripiprazole in Synthetic Mixture by UV Spectrophotometry

Mathew Ancy1, Kumar Suresh1*, Sutariya Vishnu2, Vashi Dhara1

1Department of Pharmaceutical Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat-394110, Gujarat, India

2Shree Dhanvantary Pharmaceutical Analysis and Research Centre, Managed by- Ribosome Pharma Pvt. Ltd., Surat-394110, Gujarat, India

*Corresponding Author E-mail: jdrsuresh@gmail.com

Received:  06  ,  2019; Accepted:  12  ,  2019.

ABSTRACT

The absorbance ratio method is a modification of the simultaneous equations procedure. In this study, absorbance ratio analytical method is developed in UV spectrophotometry of Vortioxetine and Aripiprazole in synthetic mixture. The measurements were carried out at wavelengths of 225 and 255 nm. The 255nm is the λmax of Aripiprazole & 225nm is the isobestic point. The linear correlation of Isobestic point (r2=0.997) was obtained in the range of 2-20 μg/ml and for Aripiprazole the linear correlation range (r2=0.998) was obtained in the range of 2-32 μg/ml. The method was successfully used for absorbance ratio method of Vortioxetine and Aripiprazole in synthetic mixture form without any interference from excipients and prior separation.

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KEYWORDS

Vortioxetine, Aripiprazole, UV visible spectrophotometry, Method Validation, absorbance ratio method.

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