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Asian Journal of Pharmaceutical Research
Year : 2019, Volume : 9, Issue : 1
First page : ( 12) Last page : ( 18)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2019.00003.0

Formulation and Evaluation of Immediate Release Tablet of Efavirenz by Micellar Solubilization Technique

Kulkarni Snehal B.1,*, Mr. Bari M.M.1, Dr. Barhate S. D.1, Tripathi Ashutosh2

1Department of Pharmaceutics, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Maharashtra, India, 424206

2Centurion Laboratories, Vadodara, Gujarat

*Corresponding Author E-mail: snehalbkulkarni3242@gmail.com

Online published on 15 March, 2019.

Abstract

The objective of the study was to prepare and evaluate immediate release tablet of efavirenz by using micellar solubilization technique to improve solubility and dissolution rate of poorly water soluble drug efavirenz. The tablets were prepared by wet granulation method using sodium lauryl sulphate as surfactant and crosscarmellose sodium and crospovidone as a superdisintegrants. Compatibility study was carried out by using FTIR and DSC found there was no drug-excipient interaction. F1-F9 batches were prepared and F9 batch showed good pre and post compression results, F9 batch showed disintegration time 1: 34 min. and 98.99% drug release within 30 min. Also F9 batch was compared with marketed formulation showed better release of drug.

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Keywords

Efavirenz, Immediate release tablet, SLS, Crosscarmellose sodium, Crospovidone.

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