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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 4
First page : ( 215) Last page : ( 220)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00036.9

Effect of Nimodipine alone and in combination with Gabapentin against Pentylenetetrazole induced Seizures in Mice

Joshi Yogesh R.1, Sapkale Prabodh V.1, Patil Pramod P.2,*

1SES's Arunamai College of Pharmacy, Mamurabad-425001 Dist-Jalgoan (M.S.) India

2SES's R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur

*Corresponding Author E-mail: nocturnalpramod@gmail.com

Online published on 25 December, 2018.

Abstract

Epilepsy is the major disorder of CNS affecting the large population, and it is a clinical condition arising from an abnormal and excessive discharge of a set of neurons in the brain. The symptoms may vary in different types of seizure and patients condition from alterations in consciousness and affecting major functions of brain which controls motor, sensory, autonomic, or psychic events. There are several different drugs are used in long term treatment of epilepsy in this study we have evaluated the effect of Nimodipine alone and in combination with Gabapentin Against Pentylenetetrazole Induced Seizures in Mice the results shows that NMD alone has mild anticonvulsant action against PTZ induce seizure, while in combination with gabapentin produced a synergistic and potent action as compared to gabapentin alone so the combination of nimopdipine, with gabapentin may be promising for the treatment of epilepsy.

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Keywords

Epilepsy, Gabapentin, Nimodipine Pentylenetetrazole Induced Seizures in Mice.

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