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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 3
First page : ( 151) Last page : ( 157)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00027.8

Preliminary Phytochemical Investigation and In Vitro Anti Bacterial Studies of Polycarpaea aurea Wight and Arn (Caryophyllaceae) Emulgel

Basha D Jamal1,*, Murthy BR Srinivas2, Prakash P2, Anuradha KC2

1Department of Pharmacognosy, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati, Andhra Pradesh, India-517503

2Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati, Andhra Pradesh, India-517503

*Corresponding Author E-mail: jamal0210@gmail.com

Online published on 24 October, 2018.

Abstract

Herbal medicine has become item of global importance both medicinal and economical. Natural medicine from a plant origin is still used as exceptional therapeutic agents especially for treating bacterial, fungal, viral, protozoal and helementic infections. Polycarpaea aurea Weight and Arn perennial herb belongs to Caryophyllaceae. It is commonly known as Rathirajuma. The whole herb traditionally used for the treating microbial infections, diabetes and dysentery effectively. In the present study an attempt was made to formulate emulgel containing methanolic plant extract. The authenticated plant powder drug subjected to successive solvent extraction for the screening of active phytochemical compounds. Different emulgels were prepared by using constant amount of gelling agent and by varying penetration enhancers i.e lavender oil (F1), eucalyptus oil (F2), orange oil (F3) and mentha oil (F4). Emulgels were further subjected to evaluation of physical properties like colour, pH, consistency, spreadability and viscosity. The emulgels were evaluated for antibacterial efficiency by agar diffusion method against gram +ve and gram-ve strains. All formulations were found to be optimum in terms of pH, colour, drug content, viscosity and extrudability. Maximum release was shown by F3 (96%). The formulation F3 showed greatest zone of inhibition and it showed potential antibacterial activity against various gram +ve and gram-ve strains than the remaining formulations and standard ofloxicin drug.

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Keywords

Polycarpaea aurea, emulgel, penetrant enhancers, evaluation, successive solvent extraction.

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