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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 3
First page : ( 136) Last page : ( 144)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00024.2

Formulation and Evaluation of Candesartan Cilexetil Mouth Dissolving Tablet by using Natural Superdisintegrant

Ragade S. M.1,*, Bari M. M.2, Barhate S. D.2

1Ambedkar Nagar, Bhusawal, Dist-Jalgaon, Maharashtra, India. 425201

2Shri Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Dist-Jalgaon, Maharashtra, India

*Corresponding Author E-mail: ragadesapna0206@gmail.com

Online published on 24 October, 2018.


The objective was to isolate natural superdisintegrants and prepare mouth dissolving tablet of candesartan cilexetil using that isolated natural superdisintegrants, as an alternative for the synthetic superdisintegrant. Also the comparision of natural superdisintegrants on D.T and drug release. Isapghulla seeds and fenugreek seeds mucilages were isolated manually by extraction. The isolated mucilages were dried and used in the formulation of candesartan cilexetil MDT by direct compression method. Organoleptic, phytochemical and physicochemical parameters of mucilages were performed. Precompression and post compression parameters were performed and batch CCMP4 showed that all the parameters were evaluated satisfactorily. In vitro dissolution of candesartan cilexetil MDT of CCMP4 was found to be, 98.16% within 15 minutes and D.T 8 seconds. As compared to CCMF3 was found to be, 81.90% within 20 minutes, and D.T 26 seconds. It was concluded that candesartan cilexetil mouth dissolving tablets were prepared successfully by using isapghulla seeds and fenugreek seeds dried mucilages, which are the alternative to the synthetic superdisintegrants. It was also concluded that isapghulla seeds dried mucilage as natural superdisintegrant, rapid disintegration time and good drug release, than fenugreek seeds dreid mucilage.



Isapghulla fenugreek seeds dried mucilages, natural, synthetic superdisintegrants, mouth dissolving tablet, candesartan cilexetil.


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