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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 3
First page : ( 119) Last page : ( 124)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00021.7

Formulation and Evaluation of Metoprolol Orodispersible Tablets by Super Disintegration Method

Rangu Nirmala1,*, Kumari B. Chaitanya2, Akula Ganesh3, Dr. Jaswanth A4

1Department of Pharmaceutics, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312 (India)

2Department of Pharmaceutics, Talla Padmavathi College of Pharmacy, karreeemabad Bodrai (V), Warangal (D), Telangana-506012 (India)

3Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel(M), Siddipet (D), Telangana-502312 (India)

4Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312 (India)

*Corresponding Author E-mail: rangunirmala@gmail.com

Online published on 24 October, 2018.

Abstract

The present study aims to formulate and evaluate oro dispersible tablets of Metoprolol, a drug that is used for the treatment of chest pain (angina) was prepared by using superdisintegration method and also optimize the best formulation. The study involved different excipients which were tested for their compatibility with Metoprolol by the FT-IR studies. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Metoprolol which were used for the preparation of Metoprolol oral disintegrating tablets. Oral disintegrating tablets of Metoprolol were prepared by direct compression method by the addition of super disintegrants. Seven batches (F1-F7) of oral disintegrating tablets of Metoprolol were prepared by using super disintegrants like Sodium starch glycolate and Croscarmellose in variable concentrations along with other excipients for the development of optimized formulation. All the formulations were subjected to evaluation studies of weight variation, hardness, friability, drug content, Wetting time, in-vitro disintegration, in vitrodissolution studies and are found to be within the limits.

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Keywords

Oro dispersible tablet (ODT), Metoprolol, Direct compression, Superdisintegration Method, Anti angina activity.

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