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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 2
First page : ( 99) Last page : ( 103)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00017.5

Hypoglycemic activity of Leaves of Bougainvillea spectabilis extract in Streptozotocin-Induced Diabetic Rats

Devi M.R. Chitra1,*, Dr. Ramesh B.2

1Assistant Professor in Biochemistry, Navarasam Arts and Science College for women, Arachalur, Erode

2Associate Professor in Biochemistry, PSG College of Arts and Science, Coimbatore, Tamilnadu, India

*Corresponding Author E-mail: jvchrsty@yahoo.co.in

Online published on 7 July, 2018.

Abstract

Diabetes mellitus is a disease in which blood glucose levels are above normal. The β cells of the pancreas do not make sufficient insulin. Herbal drugs treat diabetes by improving insulin sensitivity, increasing insulin production and/or decreasing the amount of glucose in blood. The present study was aimed to investigate antidaibetic activity of methanolic leaf extract of Bougainvillea spectabilis (B. spectabilis) alone and in combination with glibencliamide in Streptozotocin induced diabetic rats. Primarily acute toxicity study and oral glucose tolerance test were performed. The powdered plant was successfully extracted with methanol by using soxhlet extractor. The Wister strains of male albino rats were used for present study. The methanol extracts of B. spectabilis (200mg/kg and 400mg/kg) were administered to both normal and streptozotocin induced diabetic rats at defined time intervals. Blood glucose levels were measured at 0, 30, 60, 120 minutes and 0, 7, 14, 21 and 28th day after oral administration of extracts. Of the doses test, highest anti-hyper glycemic effect was observed by the extract of leaves at 400mg/kg after a week treatment. B. spectabilis extract exhibited significant hypoglycemic activity at different doses and intervals. The toxicity study results showed that the medium lethal dose (LD50) of the extract is higher than 2g/kg body weight, and hence, in a single dose administration, the plant extract had no adverse effect. Bougainvillea spectabilis methanol extract exhibited potent hypoglycemic activity.

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Keywords

Hypoglycemic activity, leaves, blood glucose level, Bougainvillea spectabilis, streptozotocin.

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