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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 2
First page : ( 61) Last page : ( 70)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00011.4

Formulation and Evaluation of Bimolar Release of Ciprofloxacin HCl from Bilayer Gastro-Retentive Floating System.

Sahoo Bijay Kumar*, Pattajoshi Sidheswar Prasad, Pattajoshi Sandhyarani

PG Dept. of Pharma. Technology, College of Pharmaceutical Sciences, Marine Drive Road, Puri, Odisha

*Corresponding Author E-mail: dr.sahoo14@gmail.com

Online published on 7 July, 2018.


The purpose of this investigation was to prepare a gastro-retentive drug delivery system of Ciprofloxacin HCl(CFH). The present study delineates a systematic approach for design and development of hydrodynamically balanced tablets of CFH to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablets of CFH were prepared employing two different grades namely HPMC K4M and HPMC K100M by effervescent technique. Sodium bicarbonate was incorporated as a gas-generating agent. Drug-excipients compatibility studies were conducted using FTIR spectra. The floating tablets were evaluated for physical characteristics viz. uniformity of weight, hardness, friability, drug content, swelling index, in vitro buoyancy. Further, tablets were evaluated for in vitro release characteristics. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled racially and axially during in vitro buoyancy studies. HPMC K15M based matrix tablets showed significantly greater swelling indices compared with other batches. The tablets exhibited prolonged drug release profiles while floating over the dissolution medium. In vitro release mechanism was evaluated by subjecting the dissolution data to various kinetic models and the drug release was found to best fit to Korsemeyer-Peppas equation and followed by Higuchi model and Zero order rate kinetics. Comparison study with marketed product CFH showed that the optimized formulation F3 has better control over release rate in comparison with the marketed product. Overall this formulation could be more effective, convenient and patient compliance.


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