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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 1
First page : ( 33) Last page : ( 35)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00006.0

Evaluation of anti-inflammatory activity of Hydroalcoholic extract of Ananas cosmosus fruit peel by HRBC membrane stabilisation.

Mr. Gorla Uma Sankar*, Dr. Savithri M., Dr. Rao G.S.N. Koteswara, Ms. Niharika Y., Ms. Sathya P. Devi Sree, Ms. Harika V.

Viswanadha Institute of Pharmaceutical Sciences, Visakhapatnam, Andhra Pradesh, India

*Corresponding Author E-mail: umasankargorla@gmail.com

Online published on 2 June, 2018.

Abstract

Objectives

To evaluate invitro anti-inflammatory activity of hydroalcoholic extract of Ananas cosmosus fruit peel by HRBC membrane stabilisation.

Methods

Hydroalcoholic extract was prepared by soxhlet extraction and thereafter subjected for membrane stabilisation assay to evaluate anti-inflammatory property. 10% human red blood cell suspension was subjected to hyptonicity induced hemolysis and inhibition of membrane damage by the extract was compared to the standard drug diclofenac sodium.

Results

Hypotonicity induced HRBC membrane lysis was inhibited by hydroalcoholic extract of Ananas cosmosus fruit peel in a concentration dependent manner. Hydroalcoholic extract showed 72.86% protection of HRBC membrane at 250μg/ml and showed significant membrane stabilisation compared with standard drug diclofenac sodium at the same concentrations.

Conclusion

Ananas cosmosus fruit peel extract showed appreciable HRBC membrane stabilisation and may have potential anti-inflammatory property. Further analysis is to be carried out to isolate active chemical constituent responsible for anti-inflammatory activity and its mechanism involved.

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Keywords

Ananas cosmosus, HRBC membrane, anti-inflammatory, hemolysis, soxhlet.

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