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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 1
First page : ( 11) Last page : ( 16)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00003.5

Studies on Derivative Spectroscopy and Area Under Curve UV-Spectrophotometric Methods for Estimation of Apremilast in Bulk and In-house Tablets

Chaudhari Suraj R.*, Patil Amod S.**, Shirkhedkar Atul A.***

Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule (MS), India, 425 405

*Corresponding Author E-mail: chaudharisuraj72@gmail.com

**patilamod.s@gmail.com

***shirkhedkar@gmail.com

Online published on 2 June, 2018.

Abstract

The proposed methods are new, simple, precise and accurate derivative spectroscopy and area under curve method was developed for the estimation of Apremilast in bulk and in-house tablets. Apremilast is phosphodiesterase-4 inhibitor; soluble in methanol. In this paper four simple Spectrophotometric methods were used for estimation of Apremilast, the proposed study was performed on double beam UV-VIS Spectrophotometer (UV-2450, Shimadzu, Japan). Apremilast was directly determined at 230 nm. The methods obey Beer's law in the range of 2–12 μg/mL, where the accuracy was found to be in the range of 98–101%. Furthermore the precision of methods were calculated in terms of % RSD less than 2 shows methods were precise. The developed methods were validated according to ICH guidelines. The described methods can be routinely used for determination of Apremilast in bulk and pharmaceutical formulations.

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Keywords

Apremilast, UV-Spectroscopy, Area Under Curve, Psoriasis, Derivative Spectrophotometry.

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