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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 1
First page : ( 11) Last page : ( 16)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00003.5

Studies on Derivative Spectroscopy and Area Under Curve UV-Spectrophotometric Methods for Estimation of Apremilast in Bulk and In-house Tablets

Chaudhari Suraj R.*, Patil Amod S.**, Shirkhedkar Atul A.***

Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule (MS), India, 425 405

*Corresponding Author E-mail: chaudharisuraj72@gmail.com



Online published on 2 June, 2018.


The proposed methods are new, simple, precise and accurate derivative spectroscopy and area under curve method was developed for the estimation of Apremilast in bulk and in-house tablets. Apremilast is phosphodiesterase-4 inhibitor; soluble in methanol. In this paper four simple Spectrophotometric methods were used for estimation of Apremilast, the proposed study was performed on double beam UV-VIS Spectrophotometer (UV-2450, Shimadzu, Japan). Apremilast was directly determined at 230 nm. The methods obey Beer's law in the range of 2–12 μg/mL, where the accuracy was found to be in the range of 98–101%. Furthermore the precision of methods were calculated in terms of % RSD less than 2 shows methods were precise. The developed methods were validated according to ICH guidelines. The described methods can be routinely used for determination of Apremilast in bulk and pharmaceutical formulations.



Apremilast, UV-Spectroscopy, Area Under Curve, Psoriasis, Derivative Spectrophotometry.


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