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Asian Journal of Pharmaceutical Research
Year : 2017, Volume : 7, Issue : 4
First page : ( 261) Last page : ( 264)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2017.00041.7

Synthesis and Evaluation of Antidiabetic Activity of Few 5-(4-(5-Substitutedphenyl)-1, 3, 4-Oxadiazlole-2-Yl) Methoxy)Benzylidene) Thiazolidine 2, 4-Dione Derivatives

Bhalerao Roshani*, Rishipathak Dinesh, Udavant Pavan, Kshirsagar Sanjay

MET'S Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, Savitribai Phule Pune University, India

*Corresponding Author E-mail:

Online published on 2 June, 2018.

Abstract

The aim of study was to synthesize a new series of Thiazolidinedione. Thiazolidinedione or glitziness forms a significant class of drug which exhibit biological activities ranging from antidiabetic, antiinflamatory, antibacterial, antifungal, antiviral, and anti-cancer. In the present study reported a systematic synthesis of thiazolidinedione. A new series of 2, 4-thiazolidinedione based derivative have been synthesize by condensation of. The structure of these compounds were establish by IR and 1H NMR. These new compound (C1-C4) were evaluated for their antidiabetic activity on albino rat. Most of compound shows significant antidiabetic activity when compare with standard drug metformin.

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Keywords

Diabetic Mellitus, Thiazolidinedione, antidiabetic activity.

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