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Asian Journal of Pharmaceutical Research
Year : 2017, Volume : 7, Issue : 2
First page : ( 106) Last page : ( 110)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2017.00018.1

Immunological evaluation of Artocarpus heterophyllus for determining its antimicrobial and anti-inflammatory activity

Shah Sumesh S1, Gupta Amit2,*, Karne Shweta1, Shinde Bharat1,2

1Department of Microbiology, Vidya Pratishthan's, Arts, Science and Commerce College, Baramati, Maharashtra, India

2Department of Zoology, Vidya Pratishthan's, Arts, Science and Commerce College, Baramati, Maharashtra, India

*Corresponding Author E-mail: amitvsbt@gmail.com; amitgupta@vsbt.res.in

Online published on 18 September, 2017.

Abstract

Objective

The objective of our present study in order to determine its antimicrobial and anti-inflammatory activity of aqueous seed extract of Artocarpus heterophyllus.

Methods

In this study, we determined its protein content from aqueous seed extract using Nanodrop method and also analyzing its antibody titre against ovalbumin (OVA) by Elisa method and also estimated its proliferation rate against OVA in lysed human whole blood. In addition, analyzing its antimicrobial activity using variable doses of seed extract against gram positive and gram negative bacteria.

Results

The results showed that seed extracts of Artocarpus heterophyllus showed higher amount of protein content at a very lower concentration and also raised its antibody production at higher doses against weak antigen OVA. In contrast, seeds extract showed its anti-inflammatory activity and this activity could be due to reduce its proliferation rate at higher doses and also showed its antimicrobial activity at the same concentration against various bacterial pathogens.

Conclusion

Overall, seed aqueous extract of Artocarpus heterophyllus showed its antimicrobial and anti-inflammatory activity.

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Keywords

Artocarpus heterophyllus, antimicrobial, anti-inflammatory, antibody, bacteria, ovalbumin.

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