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Asian Journal of Pharmaceutical Research
Year : 2017, Volume : 7, Issue : 2
First page : ( 88) Last page : ( 93)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2017.00015.6

Anti-Inflammatory activity of Ethanolic extract of Basella alba in acute and Sub-acute Model

Narapusetty Naidu1,*, Sivaiah O.1, Balanasaraiah B.1, Haranadhbabu M., Prasad B.1, Crown B. Hosanna1, Rao Ch. M. M. Prasada2

1Department of Pharmacology, Bellamkonda Institute of Technology and Sciences, Podili

2Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole

*Corresponding Author E-mail: narapusetty.naidu@gmail.com

Online published on 18 September, 2017.

Abstract

The present study is carried out to investigate the anti-inflammatory potential of Ethanolic extract of Basella alba (BA). Anti-inflammatory activity was evaluated by using Egg Albumin, Turpentine Oil and Formaldehyde as phlogistic agents. The animals were treated with doses 250mg/kg and 500mg/kg of extract and Diclofenac Sodium at a dose of 10mg/kg is used as a standard drug. The BA showed a significant anti-inflammatory activity in a dose dependent manner in all the models when compared with the standard treatment. The extract (500mg/kg) exhibited maximum antiinflammatory activity i.e., 46.25%, 44.30%, 46.40% (P<0.001) like standard Diclofenac 47.02%, 46.50%, 48.57% in Egg albumin, Turpentine oil and Formaldehyde induced methods respectively. Based on the above results, we conclude that the BA has significant anti-inflammatory activity and might prove efficacious for further design and development of agents with significant biological activity.

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Keywords

Basella alba, anti-inflammatory activity, phlogistic agents.

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