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Asian Journal of Pharmaceutical Research
Year : 2017, Volume : 7, Issue : 1
First page : ( 35) Last page : ( 48)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2017.00007.7

A Review-Ceftriaxone for Life

Khan Mohd. Yaqub*, Roy Maryada, Rawal Raj Kumar, Bansal Umesh Kumar

Prosperity 6 Pharmaceutics, Plot No. 23, EPIP Phase 2, Thana, Baddi, Himachal Pradesh-173205, India

*Corresponding Author E-mail: mohdyaqubkhan19@gmail.com

Online published on 18 September, 2017.

Abstract

Ceftriaxone for injection, USP is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is (6R, 7R)-7-[2-(2-Amino-4-thiazolyl) glyoxylamido]-8-oxo-3-[[(1, 2, 5, 6-tetrahydro-2-methyl-5, 6-dioxo-as-triazin-3-yl)thio]methyl]-5-thia-1-zabicyclo [4.2.0] oct-2-ene-2-carboxylic acid, 72-(Z)-(O-methyloxime), disodium salt, sesquaterhydrate. Ceftriaxone is a third-generation of cephalosporins which is used for community acquired infections such as pneumonia and urinaly tract infections. It showed great advantage of once-daily administration based on pharmacological manner and need no renal impairment. It is stable for β-lactamases against first-or second-generations of cephalosporins. Ceftriaxone is also used for streptococcal endocarditis as alternative first-line therapeutic regimen and used for Sexually Transmited Disease (STD) such as syphilis and chancoroid.

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Keywords

Ceftriaxone, Cephalosporin, β-lactamases.

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