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Asian Journal of Pharmaceutical Research
Year : 2015, Volume : 5, Issue : 3
First page : ( 125) Last page : ( 130)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2015.00019.2

Formulation Development and Evaluation of Gastro-Retentive Drug (Torsemide) Delivery System for Diuretic Drug

Jadhav Jagdish*, Mundhada Dharmendra, Mujoriya Rajesh

Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra

*Corresponding Author E-mail: raj_mujoriya@live.com

Online published on 8 December, 2015.

Abstract

Gastro-retentive Drug Delivery System is system which improves the Gastric Residence time and hence improves its bioavailability. In the current study indicates that the optimized gastro-retentive tablet of Torsemide, prepared using Sodium Alginate and HPMC K15M can successfully be employed as an oral controlled release drug delivery system. Tablet was formulated by using different Formulation indicated by F1 to F9 respectively. These formulations were evaluated for the pre compression and post compression parameters. The optimized Formulation was subjected to stability studied at 40ºC under humidity conditions (75%) for a period of four week. From the result it was observed that there was no significant change in physiochemical properties as well as in drug release profile even after storage at 40ºC for four week. In-vitro drug release study of formulation also done for optimized batch after stability study and found unaffected. High floating ability of the formulation is likely to increase its GI residence time, and eventually, improve the extent of bioavailability. Gastroretentive dosage form of Torsemide will reduce the frequency of administration of drug and helps to minimize dose of drug and side effects associated with the drug.

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Keywords

Gastro-retentive Drug Delivery System, bioavailability, Sodium Alginate, Torsemide, stability study, GI residence time.

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