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Asian Journal of Pharmaceutical Research
Year : 2015, Volume : 5, Issue : 2
First page : ( 102) Last page : ( 107)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2015.00015.5

Development and Validation of UV Spectrophotometric Method for Estimation of Lurasidone in Bulk and Pharmaceutical Formulations

Sri K. Vijaya*, Sravani S., Kumar M. Shiva

Department of Pharmaceutical Analysis, Malla Reddy College of Pharmacy, Secunderbad, Telangana

*Corresponding Author E-mail: vijayasree_2002@yahoo.co.in

Online published on 29 October, 2015.

Abstract

The UV-spectroscopic method were developed and validated for the estimation of Lurasidone HCl as per ICH guidelines. A simple, fast, accurate and precise UV-spectroscopy method was developed by using methanol: water (70: 30v/v) and acetonitrile: water (50: 50v/v) was used as the solvent in both methods. The λmax of Lurasidone was found to be 230 nm and it was proved linear in the concentration range of 2.5–15 μg/ml with a correlation coefficient value of 0.999 for both the methods. The accuracy studies of UV-spectroscopy method was performed at three different levels, i.e., 50%, 100%, and 150% and recovery was found to be in the range of 99.2 to 102.4% respectively. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.61–0.69 for both UV Method. The % RSD is <2% which indicates the accuracy and precision of the method.

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Keywords

Lurasidone, Validation, Estimation, UV spectrophotometry, methanolwater and acetonitrilewater.

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