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Asian Journal of Pharmaceutical Research
Year : 2015, Volume : 5, Issue : 2
First page : ( 90) Last page : ( 95)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2015.00013.1

Development of classical least square method for the determination of Candesartan and Hydrochlorthiazide in tablet dosage form

Daharwal S. J.*, Singh Veena D.

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India

*Corresponding Author E-mail: daharwalresearch@rediffmail.com

Online published on 29 October, 2015.

Abstract

A new simple spectrophotometric method was developed for the determination of binary mixtures of Candesartan cilexetil (CAND) and Hydrochalorothiazide (HCTZ), without prior separation. The method is based on the multi-wavelength technique i.e. classical least square (CLS) method. The tablet is determined by the multi-wavelength technique (CLS), at the wavelengths range of 215–225 nm over the concentration ranges of 2.5–50 and 1–30 μg/mL with mean recovery more than 98% for both drugs CAND and HCTZ, respectively. The proposed spectrophotometric method was validated and successfully applied for the assay of drug combination in several laboratory-prepared mixtures and commercial tablets.

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Keywords

Spectrophotometric analysis; Classical least square method; Candesartan; Hydrochlorothiazide.

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