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Asian Journal of Pharmaceutical Research
Year : 2015, Volume : 5, Issue : 2
First page : ( 78) Last page : ( 82)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2015.00011.8

Absorbance Correction Method for Simultaneous Estimation of Amlodipine Besylate and Simvastatin in Synthetic Mixture

Patel Vandana M.*, Raj Hasumati A., Jain Vineet C.

Department of Quality Assurance, Shree Dhanvantary College of Pharmacy, Kim, Surat, Gujarat, India

*Corresponding Author E-mail: vandanapatel@gmail.com

Online published on 29 October, 2015.

Abstract

A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Amlodipine besylate and Simvastatin in synthetic mixture using Absorbance correction method. At 360.80 nm (λmax of Amlodipine besylate) Simvastatin has zero absorbance so Amlodipine besylate is directly estimate at 360.80 nm. At 237.60 nm (λmax of Simvastatin) both drugs have some absorbance so Simvastatin is estimate at 237.60 nm using absorbance correction method. The method was found to be linear (r2>0.999) in the range of 5–10 μg/ml for Amlodipine besylate at 360.80 nm. The linear correlation was obtained (r2>0.999) in the range of 5–10 μg/ml for Simvastatin at 237.60 nm. The limit of determination was 0.17 μg/ml and 0.10μg/ml for Amlodipine besylate and Simvastatin, respectively. The limit of quantification was 0. 54μg/ml and 0. 32μg/ml for Amlodipine besylate and Simvastatin, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99%. The method was successfully applied for simultaneous determination of Amlodipine besylate and Simvastatin in binary mixture.

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Keywords

Amlodipine besylate, Simvastatin, Absorption correction Method.

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