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Asian Journal of Pharmaceutical Research
Year : 2015, Volume : 5, Issue : 1
First page : ( 51) Last page : ( 60)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2015.00008.8

A Review: Floatable Gastroretentive Drug Delivery System

Sneha S. Waghmare1,*, Trupti V. Kadam1, Darekar A. B.1, Saudagar R. B.2

1Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

2Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

*Corresponding Author E-mail: snehawaghmare4@gmail.com

Online published on 2 May, 2015.

Abstract

In the late years, exploratory and innovative progressions have been made in the innovative work of novel medication conveyance frameworks by overcoming physiological inconveniences, for example, short gastric habitation times and capricious gastric purging times. A few methodologies are as of now used in the prolongation of the gastric habitation times, including floating medication conveyance frameworks, swelling and stretching frameworks, polymeric bioadhesive frameworks, adjusted shape frameworks, high-thickness frameworks and other deferred gastric exhausting gadgets. The administration of sickness through solution is entering another period in which developing number of novel medication conveyance frameworks are continuously utilized and are accessible for helpful utilization. Oral maintained discharge gastroretentive measurements structures offer numerous favorable circumstances for medications with assimilation from upper parts of gastrointestinal tract and for those acting mainly in the stomach, enhancing the bioavailability of the pharmaceutical. Floating Gastroretentive Drug Delivery Systems (FGRDDS) is one among the gastroretentive measurements structures used to accomplish delayed gastric living arrangement time. The reason for composing this audit on skimming medication conveyance frameworks (FGRDDS) was to arrange the late writing with unique concentrate on the important instrument of floatation to accomplish gastric maintenance. The late advancements of FGRDDS including the physiological and definition variables influencing gastric maintenance, methodologies to plan single-unit and numerous unit coasting frameworks, and their arrangement and detailing angles are secured in point of interest. This survey likewise compresses the in-vitro strategies, in vivo studies to assess the execution and application of floating frameworks, and applications of these frameworks.

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Keywords

Floating gastroretentive drug delivery system (FGRDDS), single unit, multiple units, recent trends, in vitro-in vivo evaluation.

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